Session: 3C
نویسنده
چکیده
morphology or heart or kidney measurements were evident postmortem. At the tissue-bone interface, mean ∆T in vivo (1.27oC) were lower than postmortem (1.68oC) or in phantoms (1.47oC), with reductions 1mm from the focus. At 2mm from the focus, mean ∆T for all groups were approx. 1oC. The highest ∆T in a live animal was 2.92oC.Conclusions: UBM appears not to generate gross biological effects in midgestational mouse embryos, but Doppler settings and dwell time should be minimized to reduce risks of growth impairment. At tissue-bone interfaces, UBM Doppler can induce ∆T over 1oC within 1mm of the beam focus, declining to 1oC at 2mm away. Lower mean ∆T in live animals versus ex vivo indicate perfusion may dissipate acoustic heating even at 40 MHz. In phantoms, similar ∆T above and below the skull suggest heat may be conducted to skin and brain tissues. UBM appears safe for mouse imaging, with thermal effects possible at tissue-bone interfaces.
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